Description

Abacavir Sulfate CAS NO 136777-48-5 is the sulfate salt form of abacavir, a potent nucleoside reverse transcriptase inhibitor (NRTI). This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of final antiviral drug formulations. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of antiretroviral therapies for the treatment of HIV-1 infection.

Application

• Pharmaceutical API: Primary active ingredient in the manufacture of antiretroviral medications for HIV treatment.
• Fixed-Dose Combination Drugs: Used in combination with other antiretroviral agents in single-tablet regimens.
• Generic Drug Production: Sourcing for the manufacture of bioequivalent generic versions of abacavir-containing drugs.
• Clinical Research: Utilized as a reference standard or raw material in preclinical and clinical studies for new HIV therapies.
• Formulation Development: Serves as a key component in the R&D of new dosage forms, such as tablets, oral solutions, or pediatric formulations.

Basic Information

Product Name	Abacavir Sulfate
CAS No.	136777-48-5
Molecular Formula	C14H18N6O · H2SO4
Molecular Weight	670.76 g/mol (for sulfate salt)
Synonyms	(1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol sulfate; Abacavir Hemisulfate; Ziagen (brand name sulfate salt); ABC Sulfate; 1592U89 Sulfate; Cyclopropylaminopurine cyclopentenylmethanol sulfate
EINECS	Contact for details

Quality Control

Our Abacavir Sulfate is manufactured under strict quality management systems. It is typically tested to meet or exceed relevant pharmacopeial standards such as USP (United States Pharmacopeia) and EP (European Pharmacopoeia) monographs for identity, purity, and potency. Comprehensive testing includes assay, related substances, residual solvents, and microbiological examination. A Certificate of Analysis (COA) is provided with each batch to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfate Content	Conforms to theoretical value
Microbial Enumeration	Complies with EP/USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.