Description

(+)-1,2-Bis[(2S,5S)-2,5-Dimethylphospholano]Benzene is a high-value chiral phosphine ligand, specifically a Josiphos-type ligand, essential for creating highly selective asymmetric catalysts. Its primary value lies in enabling efficient and enantioselective transformations, particularly in hydrogenation and carbon-carbon bond-forming reactions, which are critical for producing single-isomer pharmaceutical intermediates and fine chemicals. This ligand is indispensable for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control to develop novel active ingredients and high-performance compounds.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Pharmaceutical Intermediate Manufacturing: Used in the production of chiral active pharmaceutical ingredients (APIs) for drugs targeting central nervous system, cardiovascular, and metabolic diseases.
• Agrochemical Synthesis: Employed in the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Cross-Coupling Reactions: Facilitates asymmetric versions of Suzuki, Heck, and other cross-coupling reactions for constructing complex chiral molecules.
• Academic & Industrial R&D: A vital tool for method development and discovery chemistry in laboratories focused on asymmetric synthesis.
• Fine Chemical Production: Applied in the manufacture of specialty flavors, fragrances, and advanced material precursors requiring high enantiomeric purity.

Basic Information

Product Name	(+)-1,2-Bis[(2S,5S)-2,5-Dimethylphospholano]Benzene
CAS No.	136735-95-0
Molecular Formula	C18H28P2
Molecular Weight	306.36 g/mol
Synonyms	(S,S)-(-)-1,2-Bis(2,5-dimethylphospholano)benzene; (S,S)-1,2-Bis[(2,5-dimethylphospholan-1-yl)]benzene; Josiphos ligand SL-J009-1; (2S,5S)-(-)-1,2-Bis(2,5-dimethylphospholano)benzene; (S,S)-DMBzBPE; (S,S)-1,2-Bis(2,5-dimethylphospholanyl)benzene; (1S,1'S)-(-)-1,1'-Bis(2,5-dimethylphospholano)ferrocene derivative ligand; Chiral dimethylphospholano benzene ligand
EINECS	Contact for details

Quality Control

Our (+)-1,2-Bis[(2S,5S)-2,5-Dimethylphospholano]Benzene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR spectroscopy, to ensure high chemical and enantiomeric purity suitable for sensitive catalytic applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, this material must be stored under an inert atmosphere (argon or nitrogen). Recommended storage temperature is 2-8°C for long-term stability. The container should be kept in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.