Description

Valacyclovir Hcl is the hydrochloride salt of the antiviral prodrug valacyclovir, a key pharmaceutical intermediate and active pharmaceutical ingredient (API). This compound is critically important for its role in the synthesis of effective antiviral medications, offering improved bioavailability over its parent compound. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of antiviral therapies targeting herpes simplex virus (HSV), varicella-zoster virus (VZV), and other related conditions.

Application

• Pharmaceutical API Synthesis: Primary use as the active pharmaceutical ingredient in the manufacture of finished antiviral dosage forms.
• Antiviral Drug Production: Essential intermediate for producing medications indicated for the treatment of herpes zoster (shingles), genital herpes, and cold sores.
• Clinical Research & Development: Used in preclinical and clinical studies for developing new antiviral formulations and delivery systems.
• Generic Drug Manufacturing: A critical component for companies producing generic versions of branded antiviral drugs containing valacyclovir.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical testing in pharmaceutical labs.
• Biochemical Research: Utilized in virology and molecular biology research to study viral replication mechanisms and inhibition.

Basic Information

Product Name	Valacyclovir Hcl
CAS No.	136489-37-7
Molecular Formula	C13H20N6O4 • HCl
Molecular Weight	360.80 g/mol
Synonyms	Valacyclovir Hydrochloride; L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl ester, monohydrochloride; Valtrex Impurity; BW256U87 hydrochloride; Zelitrex; VACV HCl; 2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate hydrochloride
EINECS	Contact for details

Quality Control

Our Valacyclovir Hcl is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications, including identification, assay, impurity profiling, and residual solvent analysis. Certificates of Analysis (COA) documenting compliance with relevant specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Microbial Limits	Meets Ph. Eur./USP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.