Description

Abacavir is a potent synthetic carbocyclic nucleoside analog with significant antiviral activity. This compound is a critical active pharmaceutical ingredient (API) primarily valued for its role in inhibiting the reverse transcriptase enzyme of the human immunodeficiency virus (HIV). It is an essential component in the formulation of combination antiretroviral therapies for the treatment of HIV-1 infection. Pharmaceutical manufacturers and research institutions globally require high-purity Abacavir CAS NO 136470-78-5 for drug development and production.

Application

• Antiretroviral Drug Manufacturing: Primary use as the active pharmaceutical ingredient (API) in fixed-dose combination tablets for HIV-1 therapy.
• Pharmaceutical Research & Development: Serves as a key reference standard and intermediate in the discovery and development of new nucleoside reverse transcriptase inhibitors (NRTIs).
• Generic Drug Formulation: Used by generic pharmaceutical companies in the production of bioequivalent versions of branded HIV medications.
• Clinical Trial Material: Supplied as a GMP-grade material for use in Phase I-III clinical studies investigating new HIV treatment regimens.
• Analytical Testing: Employed as a high-purity standard in quality control laboratories for HPLC, LC-MS, and other analytical methods.

Basic Information

Product Name	Abacavir
CAS No.	136470-78-5
Molecular Formula	C14H18N6O
Molecular Weight	286.33 g/mol
Synonyms	Abacavir Sulfate; Ziagen; ABC; (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; Cyclopropavir; 1592U89; GW 1592; C14H18N6O
EINECS	Contact for details

Quality Control

Our Abacavir is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets the stringent specifications required for pharmaceutical use, including compliance with relevant pharmacopeial standards (e.g., USP, EP). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.