Description

Abacavir 5’-Phosphate CAS NO 136470-77-4 is a critical nucleotide analog intermediate, specifically the phosphorylated prodrug form of the antiretroviral agent Abacavir. This compound is essential for enhancing the bioavailability and intracellular activation of the parent drug, making it a key building block in advanced pharmaceutical synthesis. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of next-generation HIV/AIDS therapeutics and related antiviral medications.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a vital phosphorylated intermediate in the manufacturing process of Abacavir sulfate, a nucleoside reverse transcriptase inhibitor (NRTI).
• Antiviral Drug Development: Used in research and development of novel nucleotide analog prodrugs targeting HIV-1 and HIV-2.
• Pharmaceutical Research: Employed as a reference standard and biochemical tool in pharmacokinetic and metabolic pathway studies.
• Prodrug Formulation: Key component in the design of prodrug strategies aimed at improving drug delivery and therapeutic efficacy.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for antiviral active ingredients under cGMP conditions.

Basic Information

Product Name	Abacavir 5’-Phosphate
CAS No.	136470-77-4
Molecular Formula	C14H19N6O4P
Molecular Weight	366.32 g/mol
Synonyms	Abacavir Phosphate; Abacavir 5'-Monophosphate; (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol 5'-(dihydrogen phosphate); (1S-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol 5'-(dihydrogen phosphate); Abacavir 5'-Phosphate Ester; Ziagen 5'-Phosphate (related); ABC 5'-Phosphate; Cyclopropylaminopurine cyclopentenylmethanol phosphate
EINECS	Contact for details

Quality Control

Our Abacavir 5’-Phosphate is manufactured and tested to meet stringent quality standards suitable for pharmaceutical research and development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and reliability. A Certificate of Analysis (COA) detailing specific results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment. We adhere to a quality management system to support our commitment to supplying high-purity intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated or nitrogen-purged environments.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.