Description

L-Phenylalanine (3-13C) is a stable isotope-labeled analog of the essential amino acid L-Phenylalanine, where the carbon atom at the 3-position is enriched with the Carbon-13 isotope. This compound is critical for advanced research and development, providing a precise tracer for metabolic pathway analysis and protein dynamics studies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers engaged in nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and isotopic labeling applications.

Application

• Biomedical Research Tracer: Used as a stable isotopic tracer in metabolic flux analysis and pharmacokinetic studies to track the incorporation of phenylalanine into proteins and other metabolites.
• NMR Spectroscopy Standard: Serves as an internal standard or reference compound in Nuclear Magnetic Resonance (NMR) spectroscopy for structural elucidation and quantitative analysis.
• Mass Spectrometry (MS): Employed in LC-MS and GC-MS methods as a labeled internal standard for the accurate quantification of endogenous phenylalanine in complex biological matrices.
• Proteomics and Protein Labeling: Facilitates the study of protein synthesis, folding, and turnover through stable isotope labeling by amino acids in cell culture (SILAC) and related techniques.
• Diagnostic Agent Development: A key precursor in the research and development of novel diagnostic agents and imaging probes for medical applications.
• Nutritional & Metabolic Studies: Used in clinical and nutritional research to investigate phenylalanine metabolism, particularly in relation to disorders like phenylketonuria (PKU).

Basic Information

Product Name	L-Phenylalanine (3-13C)
CAS No.	136056-02-5
Molecular Formula	C9H1113CNO2
Molecular Weight	~166.19 g/mol (for 13C1 isotopologue)
Synonyms	(S)-2-Amino-3-(3-13C)phenylpropanoic acid; L-13C1-Phenylalanine; L-Phenylalanine-3-13C; Phenylalanine-3-13C; F-3-13C; (S)-3-13C-Phenylalanine; Isotopically Labeled L-Phenylalanine; 13C Labeled Amino Acid
EINECS	Contact for details

Quality Control

Our L-Phenylalanine (3-13C) is produced and tested under strict quality management protocols. Each batch undergoes comprehensive analytical characterization to ensure high isotopic and chemical purity, confirmed by techniques including NMR, HPLC, and MS. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and specific analytical data are provided with every shipment to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Optical Rotation	[α]D20: -33° to -36° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.