Description

L-Phenylalanine (2-13C) is a stable isotope-labeled analog of the essential amino acid L-Phenylalanine, where the carbon atom at the 2-position is enriched with the carbon-13 isotope. This compound is a critical tool for advanced research and development, enabling precise metabolic pathway tracing and quantitative analysis in complex biological systems. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and nutritional science sectors for applications in drug metabolism studies, proteomics, and the development of labeled diagnostic agents.

Application

• Biomedical Research & Drug Development: As an internal standard in mass spectrometry for the accurate quantification of phenylalanine and related metabolites in pharmacokinetic and metabolomic studies.
• Proteomics & Metabolic Pathway Analysis: For stable isotope labeling by amino acids in cell culture (SILAC) to study protein turnover, synthesis rates, and dynamic metabolic fluxes.
• Clinical Diagnostics: In the development of isotope dilution assays for the precise measurement of phenylalanine levels, crucial for diagnosing and monitoring disorders like phenylketonuria (PKU).
• Nutritional Science: To investigate amino acid absorption, distribution, metabolism, and excretion (ADME) in nutritional studies and the formulation of specialized diets.
• NMR Spectroscopy: As a probe in nuclear magnetic resonance (NMR) studies to elucidate molecular structures and dynamics without signal interference from natural abundance carbon-12.
• Production of Labeled Compounds: Serves as a key chiral building block for the synthesis of more complex carbon-13 labeled pharmaceuticals, peptides, and biochemicals.

Basic Information

Product Name	L-Phenylalanine (2-13C)
CAS No.	136056-01-4
Molecular Formula	C9H1113CNO2
Molecular Weight	166.19 g/mol (for 13C1 isotopologue)
Synonyms	(S)-2-Amino-3-(13C)phenylpropanoic acid; L-(2-13C)Phenylalanine; Phenylalanine-2-13C; L-Phe-2-13C; (S)-2-Azaniumyl-3-(13C)(phenyl)propanoate; F-2-13C; [2-13C]-L-Phenylalanine
EINECS	Contact for details

Quality Control

Our L-Phenylalanine (2-13C) is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (Atom % 13C), chemical purity by HPLC, chiral purity, and residual solvent content. We adhere to relevant industry standards for fine chemicals and stable isotope-labeled compounds.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.