Description

31-o-Demethyltacrolimus is a key chemical intermediate and reference standard in advanced pharmaceutical research and development. This compound is of significant interest for its role in the synthesis and metabolic study of Tacrolimus, a potent immunosuppressive drug. It is primarily utilized by research institutions, pharmaceutical manufacturers, and analytical laboratories engaged in the development of new immunosuppressive therapies, metabolite profiling, and quality control processes.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis and structural modification of Tacrolimus and related immunosuppressant compounds.
• Metabolite Reference Standard: Used as an analytical standard in pharmacokinetic studies to identify and quantify the O-demethylated metabolite of Tacrolimus in biological matrices.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) and metabolic pathways of macrolide immunosuppressants.
• Quality Control & Assurance: Serves as a high-purity reference material for the HPLC/LC-MS analysis and purity assessment of Tacrolimus API and its related substances.
• Process Development: Used in the development and optimization of fermentation or synthetic routes for Tacrolimus production.

Basic Information

Product Name	31-o-Demethyltacrolimus
CAS No.	135635-47-1
Molecular Formula	C₄₃H₆₉NO₁₂
Molecular Weight	804.00 g/mol
Synonyms	31-O-Demethyl Tacrolimus; 31-O-Desmethyl Tacrolimus; FK506 Metabolite M1; 31-O-Demethyl-FK506; 31-O-Desmethyl-FK506; 31-O-Demethyltacrolimus; Demethyl Tacrolimus; 31-Desmethoxytacrolimus
EINECS	Contact for details

Quality Control

Our 31-o-Demethyltacrolimus is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced chromatographic techniques. We adhere to relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the product label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing under inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.