Description

2-Fluoro-5-Methylbenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic introduction of both a reactive acyl chloride group and a fluorine substituent onto a substituted benzene ring, enabling precise molecular construction. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a fluorinated benzoyl moiety for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides where the fluorine atom improves lipophilicity and target binding.
• Liquid Crystal & OLED Material Production: Acts as a building block for fluorinated aromatic cores in electronic and display materials, contributing to improved performance and stability.
• Polymer Chemistry: Employed as a monomer or modifying agent to introduce fluorine-containing side chains into polymers, altering their chemical resistance and surface properties.
• Peptide & Protein Research: Useful as an acylating agent for modifying amino acids or for introducing fluorinated labels in biochemical probes.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for specialty chemical manufacturers offering bespoke synthesis services for client R&D projects.

Basic Information

Product Name	2-Fluoro-5-Methylbenzoyl Chloride
CAS No.	135564-61-3
Molecular Formula	C8H6ClFO
Molecular Weight	172.58 g/mol
Synonyms	5-Methyl-2-fluorobenzoyl chloride; 2-Fluoro-5-methylbenzoic acid chloride; 2-Fluoro-p-toluoyl chloride; 5-Methyl-2-fluorobenzoic acid chloride; α,2-Difluoro-5-methylbenzoyl chloride (incorrect but common misnomer); 2-Fluoro-5-methyl-benzoylchloride; 2-Fluor-5-methylbenzoylchlorid
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-Methylbenzoyl Chloride is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Certificates of Analysis (COA) documenting purity, identity, and impurity profiles are provided with each shipment and are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.