Description

6-125I-Hpp-Fsk is a specialized, radiolabeled chemical probe designed for high-sensitivity biological research and diagnostic development. This compound matters for its critical role in studying and quantifying specific biochemical pathways, particularly those involving adenylyl cyclase activation and protein kinase A signaling. It is primarily needed by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in advanced molecular pharmacology, radiopharmaceutical development, and tracer studies.

Application

• Biochemical Research: As a potent, radiolabeled forskolin derivative for investigating adenylyl cyclase activity and cAMP signaling pathways in vitro.
• Receptor Binding Assays: Used in competitive binding studies to characterize G-protein coupled receptors (GPCRs) and their ligands.
• Molecular Imaging Probe Development: Serves as a precursor or reference standard in the development of novel positron emission tomography (PET) or single-photon emission computed tomography (SPECT) imaging agents.
• Drug Discovery & Development: Employed in high-throughput screening (HTS) campaigns and mechanistic studies for central nervous system (CNS), cardiovascular, and metabolic disorder targets.
• Diagnostic Kit Manufacturing: Acts as a critical component in the production of research-use-only (RUO) or investigational diagnostic assay kits.
• Tracer Studies: Utilized in pharmacokinetic and pharmacodynamic studies to trace compound distribution and metabolism.

Basic Information

Product Name	6-125I-Hpp-Fsk
CAS No.	135159-46-5
Molecular Formula	C24H34INO6
Molecular Weight	583.44 g/mol
Synonyms	6-(125I)-Hydroxyphenylpropionylforskolin; 6-(125I)-HPP-Forskolin; 125I-HPP-FSK; 6-(p-Hydroxyphenylpropionyl)-7-deacetyl-7-[125I]iodoforskolin; 7-Deacetyl-7-[125I]iodo-6-[3-(4-hydroxyphenyl)-1-oxopropyl]forskolin; Iodine-125 Labeled HPP-Forskolin; [125I]-HPP-Fsk
EINECS	Contact for details

Quality Control

Our 6-125I-Hpp-Fsk is manufactured under stringent quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including radiochemical purity (RCP) analysis via HPLC and specific activity verification. Certificates of Analysis (COA) detailing all critical parameters, including purity and radionuclidic identity, are provided with every shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in the original lead-shielded container. The product is strictly light-sensitive and must be protected from all light exposure during handling and storage to maintain stability. Users must adhere to all local and international regulations for the safe handling, storage, and disposal of radioactive materials.

Specification

Item	Specification
Appearance	Clear to slightly colored solution
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	Contact for details
Radionuclidic Purity	≥ 99% Iodine-125
Solvent	Ethanol or specified aqueous buffer
pH (if in aqueous buffer)	6.5 - 7.5

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.