Description

(S)-(-)-2,2'-Bis[Di(3,5-Xylyl)Phosphino]-1,1'-Binaphthyl is a high-value, chiral bisphosphine ligand essential for asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, which are critical for the efficient synthesis of single-enantiomer pharmaceutical intermediates and fine chemicals. This product is specifically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones in API synthesis.
• Cross-Coupling Reactions: Facilitates asymmetric versions of Suzuki-Miyaura, Heck, and other C-C bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Key chiral inducer in the production of enantiomerically pure active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the synthesis of chiral herbicides, fungicides, and pesticides for enhanced efficacy.
• Academic & Industrial R&D: A vital tool for developing new catalytic methodologies and exploring novel reaction pathways.
• Fine Chemical Production: Enables the commercial-scale manufacture of specialty flavors, fragrances, and electronic chemicals with high optical purity.

Basic Information

Product Name	(S)-(-)-2,2'-Bis[Di(3,5-Xylyl)Phosphino]-1,1'-Binaphthyl
CAS No.	135139-00-3
Molecular Formula	C52H48P2
Molecular Weight	734.89 g/mol
Synonyms	(S)-(-)-2,2'-Bis(Bis(3,5-dimethylphenyl)phosphino)-1,1'-binaphthyl; (S)-DM-BINAP; (S)-3,5-Xyl-BINAP; (S)-3,5-Xyl-4-MeO-BINAP (common misnomer); (S)-2,2'-Bis(di-3,5-xylylphosphino)-1,1'-binaphthyl; (S)-(-)-2,2'-Bis(di-m-xylylphosphino)-1,1'-binaphthyl; (S)-Bisphosphine Ligand (DM-BINAP type)
EINECS	Contact for details

Quality Control

Our (S)-(-)-2,2'-Bis[Di(3,5-Xylyl)Phosphino]-1,1'-Binaphthyl is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric excess. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and identity. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and moisture-sensitive; the original sealed container should only be opened in a controlled, dry, and oxygen-free environment.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.