Description

Adenosine-8-14C 5'-Monophosphate Diammonium Salt is a radiolabeled derivative of adenosine monophosphate (AMP), a fundamental nucleotide involved in cellular energy transfer and signaling. This compound is specifically labeled with carbon-14 at the 8-position of the adenine ring, making it an essential tool for tracing and quantifying metabolic pathways in biochemical and pharmacological research. It is primarily used by scientists and researchers in pharmaceutical development, metabolic studies, and enzymology who require precise tracking of nucleotide incorporation and turnover.

Application

• Metabolic Pathway Tracing: Used as a radiotracer in studies of purine metabolism, energy charge (ATP/ADP/AMP ratios), and nucleotide recycling within cells.
• Enzyme Kinetics & Assay Development: Serves as a labeled substrate for characterizing the activity of enzymes such as adenylate kinase, 5'-nucleotidases, and various phosphodiesterases.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the metabolic fate of nucleotide-based pharmaceuticals.
• Biochemical Research: Facilitates the study of signal transduction pathways where AMP acts as a secondary messenger or precursor to cyclic AMP (cAMP).
• Nucleic Acid Research: Can be used in studies investigating the salvage pathways for nucleotide synthesis and incorporation into RNA.
• Quality Control & Reference Standard: Acts as an analytical standard in HPLC or LC-MS methods for quantifying AMP levels in biological samples.

Basic Information

Product Name	Adenosine-8-14C 5'-Monophosphate Diammonium Salt
CAS No.	134907-91-8
Molecular Formula	C10H14N6O7P • 2(NH3) *
Molecular Weight	~ 456.3 g/mol (unlabeled form) *
Synonyms	8-14C-AMP Diammonium Salt; Adenosine-8-14C 5'-Monophosphate Diammonium; 8-Carbon-14-labeled AMP Diammonium Salt; 5'-AMP-8-14C Diammonium Salt; [(2R,3S,4R,5R)-5-(6-Amino-8-14C-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate diammonium salt; 8-14C-Adenylic Acid Diammonium Salt; 8-14C-Adenosine 5'-Monophosphate Diammonium Salt; 8-14C-Adenosine 5'-Phosphate Diammonium Salt
EINECS	Contact for details

* Note: Molecular weight is approximate for the unlabeled compound. Exact weight varies with specific activity of the carbon-14 label.

Quality Control

Every batch of our radiolabeled compounds is produced and tested to meet exacting standards for research use. Certificates of Analysis (COA) are provided, detailing key parameters such as radiochemical purity (typically >97% by HPLC), specific activity, and chemical purity. Our quality systems ensure traceability and consistency, supporting compliance with GLP (Good Laboratory Practice) guidelines. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container in a dedicated freezer and allow it to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Chemical Purity (HPLC, UV)	≥ 95%
Solubility	Soluble in water, slightly soluble in ethanol
Radioisotope	Carbon-14 (14C)
Labeling Position	8-Position of Adenine

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.