Description

Iso-FK-506 (Iso-Tacrolimus) is a structural isomer of the potent immunosuppressive agent Tacrolimus, identified by CAS NO 134590-88-8. This compound is of significant interest in pharmaceutical research and development, particularly for studying structure-activity relationships and metabolic pathways. It serves as a critical reference standard and intermediate for researchers and manufacturers in the life sciences sector who require high-purity, well-characterized chemical entities.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in the production of immunosuppressant drugs.
• Metabolic Studies: Employed as a key material in pharmacokinetic and drug metabolism research to understand the biotransformation of tacrolimus analogs.
• Impurity Profiling: Serves as a certified impurity standard to monitor and control the quality of active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized in vitro and in vivo studies to investigate the mechanism of action and selectivity of calcineurin inhibitors.
• Process Chemistry: Acts as an intermediate or starting material in the synthetic pathways for novel macrocyclic lactone derivatives.

Basic Information

Product Name	Iso-FK-506 (Iso-Tacrolimus)
CAS No.	134590-88-8
Molecular Formula	C44H69NO12 • H2O
Molecular Weight	822.03 g/mol (Monohydrate)
Synonyms	17-Epi-Tacrolimus; 17-Epimer of Tacrolimus; Iso-Tacrolimus; 17-Epi-FK506; (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-17-Ethyl-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone Monohydrate; FR-900520 Isomer; FK-506 Isomer
EINECS	Contact for details

Quality Control

Our Iso-FK-506 (Iso-Tacrolimus) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the stringent requirements for research and reference standard use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the results against established specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	2.0% - 4.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.