Description

n-(Deoxyadenosin-8-Yl)-2-Aminopyrene is a sophisticated biochemical adduct formed between a deoxyadenosine nucleoside and an aminopyrene fluorophore. This compound is of significant value in research for studying DNA damage and adduct formation, serving as a critical reference standard and probe. It is primarily utilized by analytical laboratories, academic research institutions, and pharmaceutical R&D departments focused on genetic toxicology, carcinogenesis studies, and advanced analytical method development.

Application

• DNA Adduct Research: Used as a well-defined reference standard in studies investigating the formation, detection, and repair of bulky DNA adducts.
• Biomarker Development: Serves as a critical calibrant in the development of sensitive analytical methods (e.g., HPLC-MS/MS, LC-fluorescence) for detecting specific DNA lesions in biological samples.
• Mechanistic Toxicology: Employed in research to understand the mechanisms of mutagenesis and carcinogenesis associated with polycyclic aromatic hydrocarbon (PAH) exposure.
• Enzymology Studies: Utilized as a substrate to study the activity and specificity of DNA repair enzymes, such as nucleotide excision repair (NER) pathways.
• Analytical Chemistry: Acts as a high-purity standard for method validation, ensuring accuracy and precision in quantitative bioanalysis.
• Pharmaceutical Safety Assessment: Applied in genotoxicity testing and safety pharmacology within drug discovery and development pipelines.

Basic Information

Product Name	n-(Deoxyadenosin-8-Yl)-2-Aminopyrene
CAS No.	134249-05-1
Molecular Formula	C26H22N6O3
Molecular Weight	466.49 g/mol
Synonyms	N-(Deoxyadenosin-8-yl)-2-aminopyrene; 8-(2-Aminopyren-1-yl)-2'-deoxyadenosine; dA-AP adduct; 2-Aminopyrene-deoxyadenosine adduct; N-(2'-Deoxyadenosin-8-yl)-2-aminopyrene; 1-(2-Aminopyren-1-yl)-2'-deoxyadenosine; DNA-2-Aminopyrene Adduct; PAH-DNA Adduct Standard
EINECS	Contact for details

Quality Control

Every batch of n-(Deoxyadenosin-8-Yl)-2-Aminopyrene is produced and analyzed under strict quality protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including chromatographic and spectroscopic analyses, to ensure compliance with research-grade standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to brown solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.