Description

Uridine-2-14C 5'-Monophosphate Ammonium Salt is a carbon-14 labeled nucleotide essential for metabolic and biochemical research. This radiolabeled compound serves as a critical tracer for studying RNA synthesis, nucleotide metabolism, and cellular energy pathways. It is primarily utilized by research scientists and pharmaceutical developers in life sciences, drug discovery, and molecular biology.

Application

• Biochemical Tracer Studies: Used to investigate the de novo and salvage pathways of pyrimidine nucleotide biosynthesis and metabolism.
• RNA Synthesis & Metabolism Research: Acts as a labeled precursor for tracking RNA synthesis, turnover, and processing in cellular and in vitro systems.
• Drug Discovery & Development: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to trace the metabolic fate of nucleotide-based pharmaceuticals.
• Enzymology Assays: Serves as a substrate for enzymes such as nucleoside kinases and phosphorylases to study enzyme kinetics and mechanism.
• Diagnostic Probe Development: Used in the research and development of diagnostic probes and imaging agents targeting nucleic acid metabolism.

Basic Information

Product Name	Uridine-2-14C 5'-Monophosphate Ammonium Salt
CAS No.	133628-72-5
Molecular Formula	C9H14N2O9P • xNH3 (where carbon-14 is at the 2-position of the uracil ring)
Molecular Weight	Contact for details
Synonyms	Uridine 5'-(dihydrogen phosphate)-2-14C ammonium salt; 2-14C-UMP ammonium salt; Uridine-5'-monophosphoric-2-14C acid ammonium salt; 5'-Uridylic-2-14C acid ammonium salt; UMP-2-14C ammonium salt; [(2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl-2-14C)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate ammonium salt
EINECS	Contact for details

Quality Control

Every batch of Uridine-2-14C 5'-Monophosphate Ammonium Salt is manufactured and analyzed under strict quality systems to ensure high chemical, radiochemical, and isomeric purity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specific activity, purity, and analytical methods (e.g., HPLC, NMR) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage of solutions, aliquot and store at recommended temperatures. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC, NMR)	Conforms to reference standard
Assay (HPLC)	≥ 95% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.