Description

3-Pyridinecarboxamide,Nevirapine CAS NO 133627-47-1 is a key pharmaceutical intermediate and a derivative of the active pharmaceutical ingredient Nevirapine. This compound is critical for the research, development, and synthesis of non-nucleoside reverse transcriptase inhibitors (NNRTIs) used in antiviral therapies. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on antiretroviral drug development and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of Nevirapine and its structural analogs.
• Antiviral Drug Research: Used in the research and development of next-generation non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV treatment.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale manufacturing of active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Academic & Institutional Research: Utilized in medicinal chemistry programs to study structure-activity relationships (SAR) of pyridine-based compounds.
• Custom Synthesis: A starting material for the custom synthesis of specialized chemical entities and novel drug candidates.

Basic Information

Product Name	3-Pyridinecarboxamide,Nevirapine
CAS No.	133627-47-1
Molecular Formula	C15H14N4O
Molecular Weight	266.30 g/mol
Synonyms	Nevirapine Impurity; Nevirapine Related Compound; 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one Impurity; 3-Pyridinecarboxamide, 11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one; Nevirapine Derivative; 11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one Related Substance
EINECS	Contact for details

Quality Control

Our 3-Pyridinecarboxamide,Nevirapine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specification results. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.