Description

Spermidine-8-14C Trihydrochloride is a carbon-14 radiolabeled derivative of the essential polyamine spermidine, specifically labeled at the 8-position of the spermidine backbone. This compound is a critical tool for researchers conducting metabolic, pharmacokinetic, and biochemical tracer studies, enabling precise tracking of spermidine uptake and utilization. It is primarily used by pharmaceutical R&D teams, academic research institutions, and CROs (Contract Research Organizations) focused on aging, autophagy, cell growth, and neuroscience.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of spermidine and related drug candidates.
• Biochemical Pathway Analysis: Essential for elucidating the polyamine biosynthesis and interconversion pathways in cellular systems.
• Autophagy and Aging Research: Enables quantitative tracking of spermidine's role in inducing autophagy and its potential anti-aging effects in model organisms.
• Nutrient Uptake and Transport Studies: Facilitates research into cellular uptake mechanisms of polyamines in various tissue types.
• Reference Standard: Serves as an analytical standard for method development and validation in LC-MS or radio-HPLC assays.
• Preclinical Toxicology Studies: Employed in mass balance studies to understand the long-term biodistribution and clearance of spermidine.

Basic Information

Product Name	Spermidine-8-14C Trihydrochloride
CAS No.	133448-26-7
Molecular Formula	C7H19N3 • 3HCl (with 14C at position 8)
Molecular Weight	Contact for details
Synonyms	N-(3-Aminopropyl)-1,4-butanediamine-8-14C Trihydrochloride; 1,5,10-Triazadecane-8-14C Trihydrochloride; [8-14C]-Spermidine Trihydrochloride; Radiolabeled Spermidine Trihydrochloride; Carbon-14 Labeled Spermidine HCl
EINECS	Contact for details

Quality Control

Every batch of Spermidine-8-14C Trihydrochloride is manufactured and analyzed under strict quality systems. We guarantee high radiochemical purity and chemical purity as specified, with comprehensive testing via HPLC and radio-HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, containing data on specific activity, radiochemical purity, chemical purity, and solvent content to ensure compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98% (Chemical Purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (Residual)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.