Description

trans-4-(Trifluoromethyl)Cyclohexanecarboxylic Acid is a versatile fluorinated organic building block characterized by its rigid cyclohexane backbone and a carboxylic acid functional group. This compound is highly valued for its ability to introduce lipophilicity and metabolic stability into target molecules, making it a critical intermediate in advanced synthetic chemistry. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the central nervous system and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Advanced Material Science: Employed in the synthesis of specialty polymers and coatings to impart unique chemical resistance and surface properties.
• Organic Synthesis & Catalysis: Acts as a chiral auxiliary or a ligand precursor in asymmetric synthesis and catalytic processes.
• Chemical Research: A valuable reagent for medicinal chemistry and structure-activity relationship (SAR) studies in academic and industrial R&D laboratories.

Basic Information

Product Name	trans-4-(Trifluoromethyl)Cyclohexanecarboxylic Acid
CAS No.	133261-33-3
Molecular Formula	C8H11F3O2
Molecular Weight	196.17 g/mol
Synonyms	trans-4-(Trifluoromethyl)cyclohexane-1-carboxylic Acid; (1r,4r)-4-(Trifluoromethyl)cyclohexanecarboxylic Acid; 4-(Trifluoromethyl)cyclohexanecarboxylic Acid, trans-; 4-(Trifluoromethyl)cyclohexanecarboxylic Acid; trans-4-(Trifluoromethyl)cyclohexanecarboxylic Acid; 133261-33-3; 4-(Trifluoromethyl)cyclohexanecarboxylic acid (trans-); Cyclohexanecarboxylic acid, 4-(trifluoromethyl)-, trans-
EINECS	Contact for details

Quality Control

Our production of trans-4-(Trifluoromethyl)Cyclohexanecarboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials are subjected to comprehensive analytical testing, including HPLC, GC, NMR, and chiral purity analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for identity, purity, and impurity profiles to meet the exacting standards of pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% trans-isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.