Description

2-Chloro-4-Fluorocinnamic Acid is a high-purity fluorinated cinnamic acid derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique halogenated aromatic structure, which enables precise molecular modifications in the development of novel active compounds. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and material science sectors for creating new chemical entities and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in the development of enzyme inhibitors and receptor modulators.
• Agrochemical Research: Used in the creation of advanced herbicides, fungicides, and plant growth regulators, leveraging the bioactivity of the fluorinated cinnamate scaffold.
• Liquid Crystal & OLED Material Precursor: Serves as a foundational component for synthesizing fluorinated organic semiconductors and liquid crystal molecules for electronic displays.
• Chemical Biology Probe Development: Employed in the design and synthesis of fluorescent tags and molecular probes for studying biological processes.
• Polymer & Specialty Chemical Synthesis: Acts as a monomer or modifier for introducing halogen and fluorinated aromatic groups into polymers to alter physical properties.
• Academic & Contract Research: Essential for methodological studies in organic chemistry, including cross-coupling reactions and halogen exchange processes.

Basic Information

Item	Detail
Product Name	2-Chloro-4-Fluorocinnamic Acid
CAS No.	133220-86-7
Molecular Formula	C9H6ClFO2
Molecular Weight	200.59 g/mol
Synonyms	(E)-3-(2-Chloro-4-fluorophenyl)acrylic acid; 2-Chloro-4-fluorocinnamic acid; trans-2-Chloro-4-fluorocinnamic acid; 3-(2-Chloro-4-fluorophenyl)-2-propenoic acid; (2E)-3-(2-Chloro-4-fluorophenyl)prop-2-enoic acid; α-Chloro-β-(4-fluorophenyl)acrylic acid (related); 2-Chloro-4-fluorobenzeneacrylic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluorocinnamic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	185 - 190 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.