Description

(R)-2,2-Diphenyl-2-(Pyrrolidin-3-Yl)Acetonitrile CAS NO 133099-12-4 is a high-value, chiral nitrile compound featuring a pyrrolidine scaffold and two phenyl groups. This molecule serves as a critical chiral building block and intermediate in the synthesis of complex, biologically active molecules. It is primarily sought after by pharmaceutical R&D departments and fine chemical manufacturers for developing new therapeutic agents, particularly in central nervous system (CNS) and receptor-targeted drug discovery.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs) for neurological and psychiatric disorders.
• Asymmetric Synthesis: Utilized as a building block for constructing complex molecules with defined stereochemistry in medicinal chemistry.
• Ligand and Catalyst Development: Serves as a core structure for developing novel chiral ligands and organocatalysts used in enantioselective reactions.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes to study biological pathways and protein interactions.
• Agrochemical Research: Potential intermediate in the development of new, chiral active ingredients for crop protection.
• Academic & Industrial R&D: Used in research laboratories for methodological studies in organic synthesis and new reaction development.

Basic Information

Product Name	(R)-2,2-Diphenyl-2-(Pyrrolidin-3-Yl)Acetonitrile
CAS No.	133099-12-4
Molecular Formula	C18H18N2
Molecular Weight	262.35 g/mol
Synonyms	(R)-2,2-Diphenyl-2-(3-pyrrolidinyl)acetonitrile; (3R)-2,2-Diphenyl-1-azabicyclo[3.2.0]heptane-3-carbonitrile; (R)-α-Phenyl-α-(3-pyrrolidinyl)benzeneacetonitrile; (R)-2,2-Diphenyl-2-(pyrrolidin-3-yl)ethanenitrile; (R)-DPPA; (R)-2-(Pyrrolidin-3-yl)-2,2-diphenylacetonitrile
EINECS	Contact for details

Quality Control

Our (R)-2,2-Diphenyl-2-(Pyrrolidin-3-Yl)Acetonitrile is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. A detailed Certificate of Analysis (COA) providing purity, chiral excess, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.