Description

(R)-2,2-Dimethyl-1,3-Dioxolane-4-Propanol CAS NO 133008-08-9 is a high-purity chiral building block and protected glycerol derivative, essential for the synthesis of enantiomerically pure pharmaceuticals and fine chemicals. Its value lies in providing a stereochemically defined scaffold that enables the controlled introduction of functional groups, critical for developing active pharmaceutical ingredients (APIs) with high efficacy and minimal side effects. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications in asymmetric synthesis and chiral technology.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key starting material for the production of enantiomerically pure β-blockers, antiviral agents, and other chiral drugs.
• Asymmetric Catalyst Ligand Precursor: Used in the preparation of chiral ligands for transition metal catalysis, enabling highly selective chemical transformations.
• Protected Glycerol Derivative in Lipid Chemistry: Serves as a building block for synthesizing phospholipids, glycolipids, and other complex lipids with defined stereochemistry.
• Monomer for Specialty Polymers: Employed in the synthesis of chiral polymers and dendrimers with potential applications in advanced materials and separation science.
• Agrochemical Intermediate: Utilized in the development of chiral pesticides and herbicides to enhance target specificity and reduce environmental impact.
• Flavor and Fragrance Ingredient Synthesis: Acts as a chiral synthon for creating enantiomerically pure aroma chemicals.

Basic Information

Item	Details
Product Name	(R)-2,2-Dimethyl-1,3-Dioxolane-4-Propanol
CAS No.	133008-08-9
Molecular Formula	C8H16O3
Molecular Weight	160.21 g/mol
Synonyms	(R)-1,2-Isopropylidene Glycerol; (R)-1,2-O-Isopropylidene Glycerol; (R)-1,2-O-Isopropylidene-sn-Glycerol; (R)-2,2-Dimethyl-1,3-dioxolane-4-methanol; (R)-Solketal; (R)-(-)-1,2-Isopropylidene Glycerol; (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol; (R)-Glycerol Acetonide
EINECS	Contact for details

Quality Control

Our (R)-2,2-Dimethyl-1,3-Dioxolane-4-Propanol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. All products undergo rigorous analytical testing, including chiral HPLC, GC, and NMR, to confirm identity, purity, and optical rotation. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We can support development and commercial projects requiring compliance with cGMP, ICH guidelines, and other relevant regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Optical Rotation [α]20/D	-14.0° to -16.0° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.