Description

2,4-Difluoromandelic Acid is a fluorinated derivative of mandelic acid, serving as a versatile chiral building block and synthetic intermediate. This compound is valued for its role in introducing the difluorophenylglycine moiety, a key structural feature in advanced pharmaceutical development. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Key chiral intermediate in the synthesis of pharmaceutical compounds, particularly protease inhibitors and other bioactive molecules.
• Building block for the preparation of difluorophenylglycine derivatives used in drug discovery and medicinal chemistry.
• Precursor in the development of novel agrochemicals and specialty chemicals requiring a fluorinated aromatic structure.
• Intermediate for ligands and catalysts used in asymmetric synthesis.
• Starting material for research into fluorinated amino acids and peptides.
• Used in academic and industrial R&D for exploring structure-activity relationships (SAR) in new chemical entities.

Basic Information

Product Name	2,4-Difluoromandelic Acid
CAS No.	132741-30-1
Molecular Formula	C8H6F2O3
Molecular Weight	188.13 g/mol
Synonyms	(2,4-Difluorophenyl)(hydroxy)acetic acid; α-Hydroxy-2,4-difluorophenylacetic acid; DL-2,4-Difluoromandelic acid; 2,4-Difluorobenzene glycolic acid; Mandelic acid, 2,4-difluoro-; (±)-2,4-Difluoromandelic acid
EINECS	Contact for details

Quality Control

Our 2,4-Difluoromandelic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and oxidizing agents. The material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.