Description

Thymine-Alpha,Alpha,Alpha,6-D4 Glycol is a deuterated derivative of thymine, a fundamental pyrimidine nucleobase. This compound is specifically designed for use as a stable isotope-labeled internal standard in advanced analytical techniques, ensuring unparalleled accuracy and reliability in quantitative measurements. It is an essential reagent for researchers and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic sectors, particularly for the analysis of nucleosides, nucleotides, and related metabolites. The product is supplied with the CAS registry number 132523-94-5.

Application

• Mass Spectrometry Internal Standard: Primary use as a quantitative reference standard in LC-MS/MS and GC-MS analysis of thymine and its metabolites.
• Pharmaceutical R&D: Critical for pharmacokinetic (PK) and pharmacodynamic (PD) studies of antiviral and anticancer drugs that target nucleic acid metabolism.
• Metabolomics & Biomarker Discovery: Enables precise quantification of thymine-related pathways in biological fluids for disease research.
• Diagnostic Assay Development: Used in the calibration and validation of clinical diagnostic kits for inborn errors of metabolism.
• Isotope Dilution Analysis: Provides high-accuracy results in environmental and food safety testing for nucleic acid contaminants.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Serves as a deuterated probe for studying molecular structure and dynamics.

Basic Information

Item	Detail
Product Name	Thymine-Alpha,Alpha,Alpha,6-D4 Glycol
CAS No.	132523-94-5
Molecular Formula	C5H4D4N2O3
Molecular Weight	144.15 g/mol (for deuterated form)
Synonyms	5-Methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-α,α,α,6-d4-glycol; [α,α,α,6-d4]-5-Methyluracil Glycol; Thymine-d4 Glycol; Deuterated Thymine Glycol; 5-Methyl-2,4(1H,3H)-pyrimidinedione-α,α,α,6-d4-glycol; Thymine (α,α,α,6-d4) Dihydrodiol; Isotopically Labeled Thymine Glycol
EINECS	Contact for details

Quality Control

Every batch of Thymine-Alpha,Alpha,Alpha,6-D4 Glycol is manufactured under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, verified by advanced analytical methods including NMR, HPLC, and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and specific tests is provided with each shipment to ensure compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.