Description

D-Proline, 4-Oxo-, Methyl Ester (9Ci) CAS NO 132431-08-4 is a high-purity, non-proteinogenic amino acid derivative characterized by its D-configuration and functionalized pyrrolidine ring. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecules with precise stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, antiviral agents, and other therapeutic compounds.
• Peptidomimetics Research: Used in the design and synthesis of conformationally constrained peptide analogs to enhance metabolic stability and bioavailability.
• Asymmetric Catalysis: Employed as a precursor for chiral ligands or catalysts in enantioselective synthesis.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme mechanisms and protein interactions.
• Agrochemical Synthesis: Acts as an intermediate in the production of advanced, chiral crop protection agents.
• Academic & R&D: Serves as a standard or starting material in methodological development and medicinal chemistry programs.

Basic Information

Product Name	D-Proline, 4-Oxo-, Methyl Ester (9Ci)
CAS No.	132431-08-4
Molecular Formula	C6H9NO3
Molecular Weight	143.14 g/mol
Synonyms	Methyl (2R)-4-oxopyrrolidine-2-carboxylate; (R)-4-Oxopyrrolidine-2-carboxylic acid methyl ester; D-4-Oxoproline methyl ester; Methyl D-4-oxoproline; (R)-1,3-Dihydro-2H-pyrrole-2-carboxylic acid, 5-oxo-, methyl ester; (R)-Methyl 4-oxopyrrolidine-2-carboxylate; (2R)-4-Oxo-2-pyrrolidinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our D-Proline, 4-Oxo-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity standards for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.