Description

Ring-Opened 7-(2-Hydroxyethyl)Guanine is a modified nucleobase derivative of guanine, featuring a ring-opened structure with a 2-hydroxyethyl substituent. This specific molecular architecture makes it a valuable advanced intermediate and research chemical for the synthesis of novel nucleoside analogs and other bioactive compounds. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing antiviral agents, anticancer drugs, and other therapeutic molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies investigating DNA/RNA damage, repair mechanisms, and the biological activity of modified nucleobases.
• Probe Development: Serves as a precursor for fluorescent or affinity-labeled probes to study enzyme interactions and nucleic acid metabolism.
• Academic Research: Fundamental chemical research in organic synthesis and medicinal chemistry for developing new therapeutic candidates.
• Fine Chemical Synthesis: Intermediate in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	Ring-Opened 7-(2-Hydroxyethyl)Guanine
CAS No.	131478-95-0
Molecular Formula	C7H9N5O2
Molecular Weight	195.18 g/mol
Synonyms	7-(2-Hydroxyethyl)guanine (ring-opened form); 2-Amino-6-[(2-hydroxyethyl)amino]-1,6-dihydro-4H-pyrimidin-4-one; RO-HEG; N7-(2-Hydroxyethyl)guanine; Guanine, 7-(2-hydroxyethyl)-, ring-opened; 1,6-Dihydro-2-amino-6-[(2-hydroxyethyl)amino]-4H-pyrimidin-4-one
EINECS	Contact for details

Quality Control

Our Ring-Opened 7-(2-Hydroxyethyl)Guanine is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.