Description

2,2-Difluoro-2-p-Tolylacetic Acid is a specialized fluorinated organic acid derivative, serving as a critical building block in advanced chemical synthesis. Its value lies in the unique reactivity imparted by the difluoromethyl group adjacent to the carboxylic acid, enabling precise molecular modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where fluorine atoms enhance biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral auxiliaries or metal-organic frameworks (MOFs) in asymmetric catalysis.
• Material Science Research: Employed in the synthesis of fluorinated polymers or liquid crystals with specialized properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, esterifications, and amide couplings to introduce the difluoro(p-tolyl)acetic acid moiety.

Basic Information

Product Name	2,2-Difluoro-2-p-Tolylacetic Acid
CAS No.	131323-10-9
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	2,2-Difluoro-2-(4-methylphenyl)acetic Acid; α,α-Difluoro-p-tolylacetic Acid; 4-Methyl-α,α-difluorobenzeneacetic Acid; p-Tolyl-α,α-difluoroacetic Acid; 2-(4-Methylphenyl)-2,2-difluoroacetic Acid; Difluoro(p-tolyl)acetic Acid; (4-Methylphenyl)difluoroacetic Acid
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-2-p-Tolylacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.