Description

4-Amino-1-[(2R,5R)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one is a high-purity nucleoside analogue intermediate of significant commercial and research importance. This compound is valued for its role as a critical building block in the synthesis of complex antiviral and pharmaceutical active ingredients. It is primarily required by manufacturers and R&D facilities in the pharmaceutical, biotechnology, and fine chemical sectors for the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral drugs.
• Antiviral Drug Research: Serves as a crucial precursor in the development and production of active pharmaceutical ingredients (APIs) targeting viral infections.
• Biochemical Research: Used in academic and industrial laboratories for studying enzyme mechanisms, nucleotide metabolism, and as a probe in molecular biology.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex, high-value organic molecules for medicinal chemistry and drug discovery programs.
• Reference Standard: Utilized as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	4-Amino-1-[(2R,5R)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
CAS No.	131086-22-1
Molecular Formula	C8H11N3O3S
Molecular Weight	229.26 g/mol
Synonyms	(-)-2'-Deoxy-3'-thiacytidine; (-)-3TC; Lamivudine Impurity; (-)-BCH-189; cis-1-(2-Hydroxymethyl-1,3-oxathiolan-5-yl)cytosine; (2R,5R)-4-Amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone; L-(-)-2',3'-Dideoxy-3'-thiacytidine; L-(-)-SddC
EINECS	Contact for details

Quality Control

Our 4-Amino-1-[(2R,5R)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (2R,5R isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.