Description

9-Methyl-D3-Adenine is a stable isotope-labeled analog of adenine, a fundamental purine base. This deuterated compound is essential for advanced analytical research, providing a critical internal standard for precise quantification in mass spectrometry. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors for metabolic studies, drug development, and proteomics.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the accurate quantification of adenine and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Used in deuterium-labeling studies to investigate purine metabolism, nucleotide synthesis, and related biochemical pathways.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities or degradation products in active pharmaceutical ingredients (APIs).
• Proteomics and Biomarker Research: Employed in stable isotope labeling by amino acids in cell culture (SILAC) and other quantitative proteomic techniques.
• Clinical Diagnostics Development: Supports the development of robust assays for monitoring disease biomarkers related to nucleotide metabolism.
• Chemical Reference Material: Used as a certified reference material (CRM) to ensure analytical method validity and laboratory proficiency.

Basic Information

Product Name	9-Methyl-D3-Adenine
CAS No.	130859-46-0
Molecular Formula	C6H4D3N5
Molecular Weight	150.16 g/mol
Synonyms	9-(Methyl-d3)adenine; Adenine-9-methyl-d3; N-Methyl-d3-adenine; 9-(Trideuteriomethyl)adenine; 9-Methyladenine-d3; Deuterated 9-Methyladenine; 9-MA-d3; Stable Isotope Labeled 9-Methyladenine
EINECS	Contact for details

Quality Control

Our 9-Methyl-D3-Adenine is manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is characterized by NMR and mass spectrometry to confirm deuteration level and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >98 atom % D), chemical purity (by HPLC), and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.