Description

(4-Chlorophenyl)-Difluoroacetic Acid is a specialized fluorinated aromatic carboxylic acid building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a chlorophenyl group and a difluoroacetate moiety, makes it a valuable precursor for creating complex molecules with tailored properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the introduction of fluorine atoms is a key strategy to modulate bioactivity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in creating molecules with enhanced metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoroacetic acid group can impart improved efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, contributing to desired dielectric and self-assembly properties.
• Advanced Polymer Modifier: Incorporated into specialty polymers to introduce fluorine, enhancing chemical resistance, thermal stability, and surface properties.
• Complex Ligand & Catalyst Development: Employed in organometallic chemistry to create novel chelating ligands for catalytic applications.
• Fluorine-18 Radiochemistry: Potential use as a precursor or model compound in the development of Positron Emission Tomography (PET) imaging agents.

Basic Information

Item	Details
Product Name	(4-Chlorophenyl)-Difluoroacetic Acid
CAS No.	130754-19-7
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	4-Chloro-α,α-difluorobenzeneacetic Acid; 2-(4-Chlorophenyl)-2,2-difluoroacetic Acid; p-Chloro-α,α-difluorophenylacetic Acid; (p-Chlorophenyl)difluoroacetic Acid; Difluoro(4-chlorophenyl)acetic Acid; 130754-19-7; 4-Chlorobenzene-difluoro-acetic acid
EINECS	Contact for details

Quality Control

Our (4-Chlorophenyl)-Difluoroacetic Acid is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and process development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, impurity profile, and physical characteristics.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container must be kept tightly closed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.