Description

Diisopropyl O,O'-Bis(Trimethylsilyl)-L-Tartrate is a high-purity, chiral silyl-protected tartrate derivative, serving as a critical intermediate in sophisticated organic synthesis. Its primary value lies in its dual role as a chiral auxiliary and a protecting group, enabling the stereoselective construction of complex molecules with high enantiomeric purity. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and advanced chiral catalysts.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Employed to induce chirality in aldol, alkylation, and Diels-Alder reactions for the production of enantiomerically pure compounds.
• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of chiral drugs, especially those targeting cardiovascular and central nervous system diseases.
• Ligand Precursor for Catalysts: Used in the preparation of chiral ligands for transition metal catalysts used in hydrogenation and cross-coupling reactions.
• Protecting Group for Diols: The bis(trimethylsilyl) group effectively protects the tartrate diol moiety under a wide range of reaction conditions.
• Research & Development: A valuable reagent in academic and industrial R&D labs for methodological development in stereoselective synthesis.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances requiring high optical purity.

Basic Information

Product Name	Diisopropyl O,O'-Bis(Trimethylsilyl)-L-Tartrate
CAS No.	130678-42-1
Molecular Formula	C16H34O6Si2
Molecular Weight	378.62 g/mol
Synonyms	L-(+)-Diisopropyl O,O'-Bis(trimethylsilyl)tartrate; Diisopropyl (2R,3R)-2,3-Bis[(trimethylsilyl)oxy]succinate; Di-iso-propyl 2,3-bis-O-(trimethylsilyl)-L-tartrate; (2R,3R)-Diisopropyl 2,3-bis(trimethylsiloxy)succinate; L-Tartaric Acid Diisopropyl Ester Bis(trimethylsilyl) Ether; DIPTBST; Bis-TMS-Diisopropyl-L-tartrate
EINECS	Contact for details

Quality Control

Every batch of Diisopropyl O,O'-Bis(Trimethylsilyl)-L-Tartrate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications. Our quality system is designed to support cGMP and ISO standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing assay, chiral purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.