Description

3,7-Dihydroxycholane-24-Sulfonate is a high-purity, functionalized bile acid derivative, specifically a sulfonated dihydroxycholane. This compound is a critical intermediate and reference standard in advanced pharmaceutical research and development, valued for its specific chemical modifications that influence biological activity and solubility. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly in the fields of hepatology, metabolic disease, and drug delivery systems.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel bile acid analogs and steroidal drugs targeting liver and metabolic pathways.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: Employed in studies investigating bile acid transporters, nuclear receptor (e.g., FXR, TGR5) modulation, and cholestatic liver disease mechanisms.
• Drug Delivery Enhancer: Explored for its potential to improve the solubility and intestinal absorption of poorly permeable active pharmaceutical ingredients (APIs).
• Metabolite Standard: Serves as an analytical standard for the detection and quantification of related metabolites in biological samples during pharmacokinetic studies.

Basic Information

Item	Details
Product Name	3,7-Dihydroxycholane-24-Sulfonate
CAS No.	130593-74-7
Molecular Formula	C24H40O7S
Molecular Weight	472.63 g/mol
Synonyms	3α,7α-Dihydroxy-5β-cholan-24-oic Acid Sulfonate; Tauro-3α,7α-dihydroxy-5β-cholan-24-oate Sulfonate; 3,7-Dihydroxy-5β-cholan-24-oic Acid Sulfonate Sodium Salt (common form); 5β-Cholan-24-oic Acid, 3,7-dihydroxy-, Sulfonate; Bile Acid Sulfonate Derivative; Cholane-24-sulfonate, 3,7-dihydroxy-; 130593-74-7 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 3,7-Dihydroxycholane-24-Sulfonate is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with high-purity standards suitable for research and pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.