Description

L-4-Hydroxyphenyl-D4-Alanine-2,3,3-D3 is a stable isotope-labeled analog of L-tyrosine, specifically deuterated at multiple positions. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and academic institutions engaged in advanced metabolic studies, pharmacokinetic research, and proteomic analysis.

Application

• Quantitative Mass Spectrometry (MS): Serves as a critical internal standard for the precise quantification of L-tyrosine and related metabolites in complex biological matrices.
• Pharmacokinetic & Metabolic Studies: Used in drug development to track the absorption, distribution, metabolism, and excretion (ADME) of tyrosine-containing compounds or related drugs.
• Proteomics & Biomarker Research: Enables accurate relative and absolute quantification of proteins and peptides in SILAC (Stable Isotope Labeling by Amino acids in Cell culture) and other isotope-coded affinity tag techniques.
• Clinical Diagnostics: Supports the development of highly accurate LC-MS/MS assays for diagnosing inborn errors of metabolism, such as tyrosinemia.
• Neuroscience Research: Facilitates the study of dopamine and catecholamine synthesis pathways where tyrosine is a key precursor.
• Food & Nutritional Science: Applied in research to analyze protein content, amino acid profiles, and nutrient bioavailability in fortified foods and supplements.

Basic Information

Product Name	L-4-Hydroxyphenyl-D4-Alanine-2,3,3-D3
CAS No.	130551-49-4
Molecular Formula	C9D7H4NO3
Molecular Weight	185.21 g/mol
Synonyms	L-Tyrosine-d7; (2S)-2-Amino-3-(4-hydroxyphenyl-2,3,5,6-d4)propionic-2,3,3-d3 acid; Deuterated L-Tyrosine; L-Tyrosine (phenyl-D4, 2,3,3-D3); L-Tyr-d7; L-4-Hydroxyphenylalanine-d7; (S)-2-Amino-3-(4-hydroxyphenyl-d4)propionic-2,3,3-d3 acid; Tyrosine (ring-D4, alanine-2,3,3-D3)
EINECS	Contact for details

Quality Control

Our L-4-Hydroxyphenyl-D4-Alanine-2,3,3-D3 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (atom % D), chemical purity by HPLC, and confirmation of structure. We support compliance with cGMP and ICH guidelines for pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95% (by NMR)
Optical Rotation	[α]20/D: Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.