Description

(S)-(-)-1-(n-(1-Ethoxycarbonyl-3-Phenylpropyl)-4-Fluorophenylalanine is a high-purity, single-enantiomer chiral intermediate of significant importance in advanced pharmaceutical synthesis. Its value lies in its role as a critical building block for the production of active pharmaceutical ingredients (APIs), particularly in the development of cardiovascular and antihypertensive drugs. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in enantioselective synthesis and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of angiotensin-converting enzyme (ACE) inhibitors and other potent API molecules.
• Asymmetric Synthesis: Used in enantioselective chemical reactions to introduce specific stereochemistry into complex drug candidates.
• Process Research & Development (R&D): Serves as a standard or starting material for developing and scaling up new synthetic routes in medicinal chemistry.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Academic Research: Utilized in university and institutional labs for studying stereochemistry, peptide mimetics, and novel therapeutic pathways.

Basic Information

Product Name	(S)-(-)-1-(n-(1-Ethoxycarbonyl-3-Phenylpropyl)-4-Fluorophenylalanine
CAS No.	130414-30-1
Molecular Formula	C23H26FNO4
Molecular Weight	399.46 g/mol
Synonyms	(S)-1-[(S)-3-Carboxy-1-oxopropyl]-N-[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-phenylalanine; (S)-N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-N-[(S)-3-carboxy-1-oxopropyl]-4-fluoro-L-phenylalanine; (S)-Fosinoprilat Ethyl Ester; Fosinopril Intermediate; (S)-(-)-Fosinopril Diacid Ethyl Ester; 4-Fluoro-L-phenylalanine derivative; (S)-1-[(S)-3-Carboxypropanoyl]-N-[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-4-fluoro-L-phenylalanine
EINECS	Contact for details

Quality Control

Our (S)-(-)-1-(n-(1-Ethoxycarbonyl-3-Phenylpropyl)-4-Fluorophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (HPLC) and chemical identity confirmation (NMR, IR, MS), to ensure it meets the stringent requirements for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.