Description

Nevirapine CAS NO 129618-40-2 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used as an active pharmaceutical ingredient (API). It is a critical component in the global fight against HIV-1 infection, forming the backbone of many antiretroviral therapy (ART) regimens. This compound is essential for pharmaceutical manufacturers and research institutions developing and producing life-saving antiviral medications and conducting related pharmacological studies.

Application

• Antiretroviral Drug Manufacturing: Primary use as the active pharmaceutical ingredient (API) in the formulation of solid oral dosage forms (tablets, capsules) for HIV-1 treatment.
• Fixed-Dose Combination Therapies: Used in combination with other antiretroviral agents (e.g., Zidovudine, Lamivudine) to create simplified, multi-drug treatment regimens.
• Pediatric HIV Formulations: Serves as a key component in developing age-appropriate oral suspensions and dispersible tablets for pediatric patients.
• Pharmaceutical Research & Development: Utilized in preclinical and clinical studies for investigating new HIV treatment protocols, drug resistance, and pharmacokinetics.
• Reference Standard: Sourced by analytical laboratories and regulatory bodies for use as a high-purity chemical reference standard in quality control and assay development.
• Process Chemistry & Intermediate Synthesis: Employed in the research-scale synthesis of novel NNRTI analogs and related chemical entities.

Basic Information

Product Name	Nevirapine
CAS No.	129618-40-2
Molecular Formula	C15H14N4O
Molecular Weight	266.30 g/mol
Synonyms	Nevirapine; BI-RG-587; NVP; 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one; 6,11-Dihydro-11-cyclopropyl-4-methyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-5-one; Viramune (Brand Name); BI RG-587; NSC-641530
EINECS	Contact for details

Quality Control

Our Nevirapine is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical applications. Quality is assured through rigorous in-process and final release testing, including identity confirmation, purity assay, and control of specified impurities. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results against relevant pharmacopeial standards (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Specific Impurity A	≤ 0.15%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.