Description

D-Glucosamine-(6-3H(N)) Hydrochloride is a tritium-labeled derivative of glucosamine hydrochloride, a fundamental amino sugar and a key building block for glycosaminoglycans. This radiolabeled compound is essential for metabolic and pharmacokinetic studies, enabling precise tracking and quantification in biological systems. It is primarily utilized by research scientists and pharmaceutical developers in the fields of biochemistry, molecular biology, and drug discovery for tracer experiments and analytical method development.

Application

• Biochemical Tracer Studies: Used to investigate the metabolic pathways and incorporation rates of glucosamine in cartilage, synovial fluid, and other connective tissues.
• Pharmacokinetic Research: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the fate of glucosamine-based compounds in vivo.
• Glycobiology Research: Serves as a labeled precursor for studying the biosynthesis of hyaluronic acid, chondroitin sulfate, and other glycosaminoglycans.
• Drug Discovery & Development: Facilitates the development and validation of analytical methods (e.g., LC-MS, scintillation counting) for new therapeutic agents targeting joint health and osteoarthritis.
• Enzyme Assay Substrate: Acts as a substrate in assays for enzymes involved in amino sugar metabolism, such as glucosamine-6-phosphate synthase.
• In Vitro Diagnostic Development: Used in the research and development of diagnostic assays related to cartilage turnover and metabolic disorders.

Basic Information

Product Name	D-Glucosamine-(6-3H(N)) Hydrochloride
CAS No.	129521-67-1
Molecular Formula	C6H12ClNO5 * 3H
Molecular Weight	~215.6 g/mol (unlabeled form: 215.63)
Synonyms	Glucosamine-6-3H Hydrochloride; (6-3H)Glucosamine HCl; 2-Amino-2-deoxy-D-glucose-6-3H hydrochloride; D-Glucosamine-6-tritium hydrochloride; Chitosamine-3H hydrochloride; Tritiated Glucosamine HCl; Radiolabeled Glucosamine Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of D-Glucosamine-(6-3H(N)) Hydrochloride is produced and analyzed under strict quality protocols to ensure high chemical purity and specific radioactivity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, specific activity, radiochemical purity, and analytical methods (e.g., HPLC, NMR) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric moisture. For long-term storage, consider storage at or below -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Specific Activity	10-40 Ci/mmol (Contact for specific value)
Radiochemical Purity (HPLC)	≥ 97%
Solvent (for solution forms)	Ethanol:Water (Contact for ratio)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.