Description

L-Lysine-6-13C Hydrochloride is a stable isotope-labeled derivative of the essential amino acid L-Lysine, where the carbon atom at the 6-position is enriched with the 13C isotope. This compound is a critical tool for advanced research and development, enabling precise metabolic pathway tracing and quantitative analysis in complex biological systems. It is primarily utilized by scientists and manufacturers in the pharmaceutical, nutritional science, and biomedical research sectors for applications requiring high isotopic purity and chemical stability.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to study central carbon metabolism, amino acid biosynthesis, and protein turnover in cell cultures, tissues, and whole organisms.
• Quantitative Proteomics & Biomarker Discovery: Serves as an internal standard in mass spectrometry-based workflows (e.g., SILAC, LC-MS/MS) for accurate protein quantification and identification of disease biomarkers.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed in the development and validation of analytical methods to track the absorption, distribution, metabolism, and excretion (ADME) of new drug candidates.
• Nutritional Research: Investigates lysine utilization, requirements, and bioavailability in human and animal nutrition studies.
• Stable Isotope-Labeled Standard (SILS) Production: Acts as a key precursor for synthesizing more complex labeled peptides, proteins, or diagnostic agents.
• NMR Spectroscopy: Facilitates structural elucidation and dynamic studies of biomolecules due to the distinct magnetic properties of the 13C nucleus.

Basic Information

Product Name	L-Lysine-6-13C Hydrochloride
CAS No.	129243-92-1
Molecular Formula	C613CH15ClN2O2 *or* C513CH15ClN2O2
Molecular Weight	~183.65 g/mol (for 13C6 labeled form)
Synonyms	(2S)-2,6-Diamino-6-13C-hexanoic acid hydrochloride; L-Lysine-6-13C HCl; 6-13C-L-Lysine monohydrochloride; [6-13C]-L-Lysine HCl; Lysine-6-13C hydrochloride; Stable isotope-labeled L-Lysine HCl; (S)-2,6-Diamino[6-13C]caproic acid hydrochloride; L-[6-13C]Lysine hydrochloride
EINECS	Contact for details

Quality Control

Our L-Lysine-6-13C Hydrochloride is manufactured under strict quality systems to ensure the highest standards of isotopic and chemical purity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment, chemical purity, and chiral purity. We adhere to relevant industry guidelines for stable isotope-labeled compounds to ensure reliability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 99 atom % 13C
Optical Rotation	[α]20/D: +19.0° to +22.0° (c=2 in 6N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.