Description

Procaine Hydrochloride, [3,5-3H] is a high-specific-activity, tritium-labeled derivative of the local anesthetic procaine. This radiolabeled compound is essential for advanced pharmacokinetic, metabolic, and receptor-binding studies, providing critical data for drug development and biochemical research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on neuroscience and pharmacology.

Application

• Pharmacokinetic and ADME Studies: Tracing the absorption, distribution, metabolism, and excretion (ADME) of procaine and related compounds in biological systems.
• Metabolic Pathway Analysis: Investigating the biotransformation and metabolic fate of procaine in vitro and in vivo.
• Receptor Binding and Displacement Assays: Used as a tracer in competitive binding studies to characterize local anesthetic interactions with biological targets.
• Biochemical Research: A tool for studying the mechanism of action, transport, and cellular uptake of amino ester-type local anesthetics.
• Analytical Method Development: Serving as an internal standard or reference material in the development of sensitive LC-MS or radio-HPLC methods.

Basic Information

Product Name	Procaine Hydrochloride, [3,5-3H]
CAS No.	129083-48-3
Molecular Formula	C13H21N2O2 • HCl (³H-labeled)
Molecular Weight	272.78 g/mol (unlabeled base)
Synonyms	2-Diethylaminoethyl 4-aminobenzoate hydrochloride (³H); Novocaine hydrochloride (³H); Ethocaine hydrochloride (³H); 4-Aminobenzoic acid 2-(diethylamino)ethyl ester hydrochloride (³H); Procaine HCl [³H]; Tropocaine; Allocaine; Kerocaine; Scurocaine
EINECS	Contact for details

Quality Control

Every batch of our Procaine Hydrochloride, [3,5-3H] is manufactured and analyzed under strict quality systems. The product undergoes rigorous testing to ensure high radiochemical purity and specific activity, confirmed by radio-HPLC and liquid scintillation counting. Certificates of Analysis (COA) detailing specific activity, purity, solvent composition, and analytical chromatograms are provided with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach ambient temperature before opening to minimize moisture ingress. For long-term storage, keep the primary container within a secondary sealed vessel with desiccant.

Specification

Item	Specification
Appearance	White to off-white solid or solution
Identification (IR / NMR)	Conforms to structure
Specific Activity	Customizable (e.g., 10-80 Ci/mmol)
Radiochemical Purity (Radio-HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 98%
Solvent (if supplied as solution)	Ethanol, Methanol, or custom
Concentration	1.0 mCi/mL (or as specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.