Description

(E)-4-Hydroxynonenal is a highly reactive and biologically significant alpha,β-unsaturated aldehyde, specifically the (E)-isomer of 4-Hydroxynonenal (4-HNE). This compound is a key marker and mediator of oxidative stress, playing a crucial role in cell signaling, apoptosis, and the pathophysiology of various diseases. It is an essential research chemical for scientists and professionals in biochemical research, pharmaceutical development, and toxicology studies, where understanding lipid peroxidation and its downstream effects is critical.

Application

• Biomedical Research: As a primary product of lipid peroxidation, used to study oxidative stress mechanisms, cell signaling pathways (e.g., MAPK, NF-κB), and apoptosis in models of neurodegenerative diseases, cardiovascular disorders, and cancer.
• Pharmaceutical Development: Employed as a reference standard and a tool compound in drug discovery programs targeting oxidative damage, for screening antioxidants, and developing therapeutic agents for conditions like diabetes and ischemia-reperfusion injury.
• Toxicology & Safety Assessment: Used to investigate the cytotoxic and genotoxic effects of reactive aldehydes, serving as a biomarker in assays to assess chemical-induced oxidative damage in cells and tissues.
• Nutritional & Food Science: Applied in studies examining the impact of dietary lipids on oxidative stress and the formation of advanced lipoxidation end-products (ALEs) in food and biological systems.
• Analytical Reference Standard: Serves as a high-purity calibrant and standard in analytical techniques such as HPLC, GC-MS, and LC-MS for the accurate quantification of 4-HNE and related aldehydes in complex biological matrices.
• Cosmeceutical Research: Utilized in studies focused on skin aging to understand the role of lipid peroxidation in photoaging and to evaluate the efficacy of topical antioxidants and anti-aging formulations.

Basic Information

Product Name	(E)-4-Hydroxynonenal
CAS No.	128946-65-6
Molecular Formula	C₉H₁₆O₂
Molecular Weight	156.22 g/mol
Synonyms	4-Hydroxy-2-nonenal; 4-HNE; (E)-4-HNE; (E)-4-Hydroxy-2-nonenal; (E)-4-Hydroxy-2-nonen-1-al; (E)-4-Hydroxynon-2-enal; 4-Hydroxy-trans-2-nonenal; Lipid peroxidation product 4-HNE
EINECS	Contact for details

Quality Control

Our (E)-4-Hydroxynonenal is produced and handled under strict quality protocols to ensure the high purity and stability required for sensitive research applications. Each batch is thoroughly characterized using advanced analytical techniques. Certificates of Analysis (COA) detailing purity, isomer specificity, and impurity profiles are provided to guarantee reproducibility and reliability in your experiments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). This product is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (HPLC/GC-MS)	Conforms
Purity (HPLC)	≥ 95% (Area %)
Isomeric Purity ((E)-isomer)	≥ 98%
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.