Description

3-(Difluoromethoxy)-2,4,5-Trifluorobenzoic Acid is a high-purity fluorinated benzoic acid derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its unique molecular structure, which is essential for constructing complex active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the difluoromethoxy and trifluoro groups contribute to biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and liquid crystals with unique electronic and surface properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a carboxylic acid component in amide bond formation for constructing complex organic molecules in medicinal chemistry.
• Fluorine Chemistry Research: An important compound for academic and industrial research focused on understanding the effects of polyfluorination on chemical reactivity and physical properties.

Basic Information

Product Name	3-(Difluoromethoxy)-2,4,5-Trifluorobenzoic Acid
CAS No.	128426-86-8
Molecular Formula	C8H3F5O3
Molecular Weight	242.10 g/mol
Synonyms	2,4,5-Trifluoro-3-(difluoromethoxy)benzoic Acid; Benzoic acid, 3-(difluoromethoxy)-2,4,5-trifluoro-; 3-(Difluoromethoxy)-2,4,5-trifluorobenzoic acid; 2,4,5-Trifluoro-α,α-difluoro-3-methoxybenzenecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)-2,4,5-Trifluorobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all test results are provided and available upon request, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its nature as a strong acid/organic solvent, handle with appropriate personal protective equipment in a fume hood.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.