Description

(R)-(-)-Citalopram CAS NO 128196-02-1 is the single enantiomer of the widely used selective serotonin reuptake inhibitor (SSRI), Citalopram. This high-purity chiral intermediate is critical for pharmaceutical research and development focused on enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers and advanced research institutions engaged in the synthesis of novel therapeutics, process optimization, and stereochemical studies related to neuropharmacology.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure (R)-Citalopram and related derivative APIs.
• Research & Development: Essential reference standard and starting material for pharmacological research, metabolic studies, and analytical method development.
• Process Chemistry: Used in route scouting and optimization for the commercial-scale production of the (R)-enantiomer.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for HPLC, LC-MS, and chiral analysis to ensure quality control.
• Asymmetric Synthesis Studies: Valuable substrate for developing and testing new chiral catalysts and synthetic methodologies.

Basic Information

Product Name	(R)-(-)-Citalopram
CAS No.	128196-02-1
Molecular Formula	C20H21FN2O
Molecular Weight	324.39 g/mol
Synonyms	(R)-Citalopram; (R)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile; (R)-1-(3-Dimethylaminopropyl)-1-(4-fluorophenyl)-5-phthalancarbonitrile; Escitalopram Impurity; (R)-Lu 10-005-B; UNII-0K47S5P26T
EINECS	Contact for details

Quality Control

Our (R)-(-)-Citalopram is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D use. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, purity, and impurities is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R)-enantiomer
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.