Description

9Alpha,11Alpha-Epidioxy-15S-Hydroxy-Prosta-5Z,13E-Dien-1-Oic Acid, Labeled With Tritium is a high-purity, tritium-labeled prostaglandin analog, a critical tool for advanced biochemical and pharmacological research. This compound serves as an essential radioligand for high-sensitivity receptor binding assays, metabolic pathway tracing, and autoradiography studies. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on inflammation, reproductive biology, and cardiovascular research, where precise tracking of prostaglandin pathways is required.

Application

• Receptor Binding Assays: Used as a high-specific-activity radioligand for studying prostaglandin receptor (e.g., FP, EP) affinity, density, and kinetics.
• Metabolic Pathway Analysis: Enables precise tracing and quantification of prostaglandin metabolic products and degradation pathways in in vitro and ex vivo systems.
• Autoradiography: Facilitates the spatial localization and visualization of prostaglandin binding sites in tissue sections for pathological and pharmacological studies.
• Drug Discovery & Development: A key tool in screening and characterizing novel anti-inflammatory or modulatory compounds targeting the arachidonic acid cascade.
• Biochemical Research: Employed in enzyme activity studies (e.g., cyclooxygenase, prostaglandin synthases) and the investigation of signal transduction mechanisms.
• Toxicology Studies: Assists in understanding the biodistribution and long-term effects of prostaglandin analogs and related therapeutics.

Basic Information

Product Name	9Alpha,11Alpha-Epidioxy-15S-Hydroxy-Prosta-5Z,13E-Dien-1-Oic Acid, Labeled With Tritium
CAS No.	127969-05-5
Molecular Formula	C20H30O5 (³H-labeled)
Molecular Weight	~350.45 g/mol (unlabeled)
Synonyms	9α,11α-Epidioxy-15S-hydroxy-prosta-5Z,13E-dien-1-oic acid (³H); [³H]-9,11-Epidioxy-15-hydroxy-prosta-5,13-dienoic acid; Tritiated PGD2 analog; Radiolabeled Prostaglandin D2 derivative; 9,11α-Epidioxy-15(S)-hydroxy-(5Z,13E)-prostadienoic acid (³H); PH]PGD2 metabolite; 9α,11α-PGD2 (tritiated); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of our tritium-labeled compounds is produced and tested under strict quality protocols to ensure exceptional radiochemical purity and specific activity. We provide comprehensive Certificates of Analysis (COA) detailing critical parameters such as radiochemical purity (by HPLC), specific activity, chemical purity, and solvent composition. Our quality systems are designed to support GLP/GMP-compliant research, ensuring data integrity and reproducibility for our clients in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as supplied. Due to the highly volatile nature of organic solvents and the light-sensitive, labile nature of the prostaglandin epoxide structure, prolonged exposure to light, heat, or air should be avoided. For long-term storage, keep in a dedicated, well-ventilated freezer designated for radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 95%
Specific Activity	Customizable (Typical range: 10-100 Ci/mmol)
Chemical Purity (HPLC)	≥ 90%
Solvent	Ethanol or Toluene/Ethanol mixture
Concentration	Customizable (e.g., 1 mCi/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.