Description

1,3-Dioxolane-2,4-Dicarboxaldehyde, (2R,4R)- is a high-purity, chiral building block of significant interest in advanced organic synthesis. Its unique structure, featuring two aldehyde groups on a protected diol scaffold, makes it a versatile precursor for constructing complex, stereodefined molecules. This compound is particularly valuable for researchers and process chemists in the pharmaceutical and fine chemical industries developing active pharmaceutical ingredients (APIs), ligands, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly those requiring specific (2R,4R) stereochemistry.
• Asymmetric Synthesis: Used in the preparation of chiral ligands, catalysts, and auxiliaries for stereoselective transformations.
• Natural Product Synthesis: Serves as a building block for the total synthesis of natural products with dioxolane or polyol motifs.
• Polymer Chemistry: A potential monomer or cross-linking agent for creating novel polymers with acetal functionality.
• Chemical Research: Employed in methodological development and exploration of new reactions involving bifunctional aldehydes.

Basic Information

Product Name	1,3-Dioxolane-2,4-Dicarboxaldehyde, (2R,4R)-
CAS No.	127903-51-9
Molecular Formula	C5H6O5
Molecular Weight	146.10 g/mol
Synonyms	(2R,4R)-1,3-Dioxolane-2,4-dicarboxaldehyde; (2R,4R)-2,4-Bis(formyl)-1,3-dioxolane; (R,R)-1,3-Dioxolane-2,4-dicarbaldehyde; (2R,4R)-2,4-Diformyl-1,3-dioxolane; (R,R)-Diformyl-1,3-dioxolane; Chiral 1,3-dioxolane-2,4-dicarboxaldehyde; (2R,4R)-Dioxolane dicarbaldehyde
EINECS	Contact for details

Quality Control

Our 1,3-Dioxolane-2,4-Dicarboxaldehyde, (2R,4R)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. Allow the container to reach room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.