Description

Saquinavir is a potent and selective inhibitor of the HIV-1 and HIV-2 protease enzymes, belonging to the class of antiretroviral drugs known as protease inhibitors. This active pharmaceutical ingredient (API) is critical for the formulation of combination therapies used in the management of Human Immunodeficiency Virus (HIV) infection. It is essential for pharmaceutical manufacturers and research institutions focused on developing and producing antiviral medications to improve patient outcomes and public health.

Application

• Antiretroviral Drug Formulation: Primary active ingredient in the manufacture of saquinavir mesylate capsules and tablets for HIV treatment.
• Combination Therapy (HAART): Used in Highly Active Antiretroviral Therapy regimens in combination with other antiretroviral agents to suppress viral replication.
• Pharmaceutical Research: Serves as a key reference standard and intermediate in preclinical and clinical research for novel HIV therapies.
• Generic Drug Production: Critical for API suppliers serving the global generic pharmaceutical market, ensuring access to affordable HIV medication.
• Drug Delivery System Development: Used in studies focusing on enhancing the bioavailability and pharmacokinetic profile of protease inhibitors.

Basic Information

Product Name	Saquinavir
CAS No.	127779-20-8
Molecular Formula	C38H50N6O5
Molecular Weight	670.85 g/mol
Synonyms	Saquinavir (base); Ro 31-8959; Invirase® (as mesylate); Fortovase® (as mesylate); (2S)-N-[(2S,3R)-4-[(3S)-3-(tert-butylcarbamoyl)-decahydroisoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinolin-2-ylformamido)butanediamide; L-735,524; HIV Protease Inhibitor Ro 31-8959
EINECS	Contact for details

Quality Control

Our Saquinavir is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your quality requirements and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.