Description

(R)-1-[2-(Trifluoromethyl)Phenyl]Ethylamine is a high-value chiral amine building block characterized by its trifluoromethylphenyl group, which imparts unique electronic and steric properties. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its stereochemistry and fluorine content are leveraged to modulate biological activity, metabolic stability, and lipophilicity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of central nervous system (CNS) drugs, enzyme inhibitors, and receptor antagonists.
• Agrochemical Synthesis: Used in constructing advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances efficacy and environmental persistence.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands in asymmetric catalysis, enabling highly enantioselective transformations.
• Material Science Research: Employed in the synthesis of specialty polymers and liquid crystals with tailored optical and electronic properties.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high enantiomeric purity and structural complexity.

Basic Information

Product Name	(R)-1-[2-(Trifluoromethyl)Phenyl]Ethylamine
CAS No.	127733-46-4
Molecular Formula	C9H10F3N
Molecular Weight	189.18 g/mol
Synonyms	(R)-α-Methyl-2-(trifluoromethyl)benzylamine; (R)-1-(2-Trifluoromethylphenyl)ethanamine; (R)-2-(Trifluoromethyl)phenethylamine; (R)-1-(α,α,α-Trifluoro-o-tolyl)ethylamine; (R)-(-)-1-[2-(Trifluoromethyl)phenyl]ethylamine; (R)-1-(2-Trifluoromethylphenyl)ethylamine; (R)-TFMPEA; (R)-2-(Trifluoromethyl)phenylethylamine
EINECS	Contact for details

Quality Control

Our (R)-1-[2-(Trifluoromethyl)Phenyl]Ethylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent oxidation and moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.