Description

Ganglioside Gm2(18,18) CAS NO 127663-77-8 is a specific, high-purity glycosphingolipid essential for advanced biochemical and neurological research. This compound is a critical component for studying cellular membrane structure, signal transduction, and the molecular basis of certain lysosomal storage disorders. It is primarily utilized by research institutions, diagnostic developers, and pharmaceutical companies engaged in neuroscience, lipidomics, and the development of therapeutic agents and diagnostic tools.

Application

• Biochemical Research Standard: Used as a high-purity reference standard in lipidomics and glycolipid analysis.
• Neuroscience Studies: Essential for investigating the role of gangliosides in neuronal cell membrane structure, function, and signaling pathways.
• Disease Mechanism Research: Critical for in vitro studies of Tay-Sachs and Sandhoff diseases, where GM2 ganglioside accumulation is a hallmark.
• Diagnostic Development: Serves as a key antigen or standard in the development of enzymatic assays and immunological tests for lysosomal storage disorders.
• Pharmaceutical R&D: Used in drug discovery programs targeting ganglioside metabolism, enzyme replacement therapies, and substrate reduction therapies.
• Cell Biology: Employed in studies of lipid rafts, membrane microdomains, and cell-to-cell recognition processes.

Basic Information

Product Name	Ganglioside Gm2(18,18)
CAS No.	127663-77-8
Molecular Formula	C86H156N4O32
Molecular Weight	1765.2 g/mol
Synonyms	GM2 Ganglioside (d18:1/18:0); II3Neu5Ac-Gg4Cer (d18:1/18:0); Ganglioside GM2 (d18:1-18:0); N-Acetylneuraminosylgalactosylglucosylceramide; Tay-Sachs ganglioside; Asialo-GM2; GgOse4Cer; β-D-Gal-(1→4)-β-D-GalNAc-(1→4)-[α-D-Neu5Ac-(2→3)]-β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Ceramide (d18:1/18:0)
EINECS	Contact for details

Quality Control

Our Ganglioside Gm2(18,18) is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards, utilizing techniques such as HPLC, MS, and NMR for characterization and verification.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in chloroform/methanol/water mixtures
Loss on Drying	≤ 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.