Description

7-(Deoxyguanosin-N(2)-Yl)Aristolactam I is a specific DNA adduct formed by the covalent binding of an aristolactam moiety to the N² position of deoxyguanosine. This compound is of significant interest as a biomarker for exposure to carcinogenic aristolochic acids, which are found in certain plants. It is primarily utilized by research institutions, toxicology laboratories, and pharmaceutical companies engaged in studies of chemical carcinogenesis, DNA damage, and metabolic activation pathways.

Application

• Biomarker Research: Critical standard for the detection and quantification of aristolochic acid-derived DNA adducts in biological samples.
• Toxicology Studies: Used to investigate the mechanisms of aristolochic acid nephropathy (AAN) and associated urothelial cancers.
• Metabolic Pathway Analysis: Employed in studies to elucidate the metabolic activation and DNA-binding profiles of aristolactams.
• Analytical Method Development: Serves as a reference standard for developing and validating sensitive analytical methods like LC-MS/MS and 32P-postlabeling.
• Cancer Etiology Research: A key tool in understanding the role of herbal medicine contaminants in the etiology of specific cancers.
• Quality Control for Reference Materials: Used to certify and calibrate other analytical standards and reagents in toxicology testing.

Basic Information

Product Name	7-(Deoxyguanosin-N(2)-Yl)Aristolactam I
CAS No.	127191-85-9
Molecular Formula	C27H25N7O7
Molecular Weight	559.53 g/mol
Synonyms	dG-AAI; 7-(Deoxyguanosin-N²-yl)aristolactam I; N²-(Deoxyguanosin-7-yl)aristolactam I; AAI-dG; Aristolactam I-deoxyguanosine adduct; 7-(2'-Deoxyguanosin-N²-yl)aristolactam I; DNA-AAI Adduct; Deoxyguanosine-aristolactam I adduct
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research chemicals. Each batch is characterized using advanced analytical techniques to confirm identity and purity. Certificates of Analysis (COA) detailing purity, identification, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment to maintain stability. This hygroscopic and light-sensitive material should be allowed to equilibrate to room temperature in a dry atmosphere before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light brown solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.