Description

8-Hydroxydeoxyguanosine 5'-Monophosphate is a modified nucleotide monophosphate, specifically an oxidized derivative of deoxyguanosine monophosphate (dGMP). This compound is of significant interest as a critical biomarker for oxidative DNA damage, reflecting the impact of reactive oxygen species on genetic material. It is primarily utilized by researchers and manufacturers in the fields of life science research, diagnostic assay development, and pharmaceutical R&D focused on aging, cancer, and metabolic diseases.

Application

• Biomarker Standard for Oxidative Stress Studies: Used as a reference standard in analytical methods (HPLC, LC-MS/MS) to quantify 8-OH-dG levels in biological samples.
• Diagnostic Kit Development: A key component in the formulation of ELISA and other immunoassay kits designed to detect oxidative DNA damage.
• Pharmaceutical Research: Employed in screening and evaluating the efficacy of antioxidant compounds and chemopreventive agents.
• Nutritional and Cosmetic Science: Used in studies assessing the protective effects of nutraceuticals and skincare ingredients against environmental oxidative damage.
• Toxicology and Environmental Health: Serves as an endpoint in assays measuring genotoxicity induced by chemicals, radiation, or pollutants.
• Enzymology Studies: Utilized as a substrate to study the activity of DNA repair enzymes, such as 8-oxoguanine DNA glycosylase (OGG1).

Basic Information

Product Name	8-Hydroxydeoxyguanosine 5'-Monophosphate
CAS No.	127027-50-3
Molecular Formula	C10H14N5O8P
Molecular Weight	363.22 g/mol
Synonyms	8-OH-dGMP; 8-Oxo-dGMP; 8-Hydroxy-2'-deoxyguanosine-5'-monophosphate; 8-Oxo-2'-deoxyguanosine-5'-monophosphate; 8-Oxo-7,8-dihydro-2'-deoxyguanosine-5'-monophosphate; Oxidized dGMP; 8-Oxoguanine deoxyribonucleoside monophosphate
EINECS	Contact for details

Quality Control

Our 8-Hydroxydeoxyguanosine 5'-Monophosphate is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive analytical and research applications. Each lot undergoes comprehensive analysis including HPLC purity assay, identity confirmation (UV, MS), and tests for moisture and related substances. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (UV)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.