Description

Methyl 3-Hydroxy-4-(Trifluoromethyl)Benzoate is a high-purity fluorinated aromatic ester building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a phenolic hydroxyl group and a trifluoromethyl substituent on the benzoate ring, enabling precise molecular modifications. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring the bioisosteric and metabolically stable trifluoromethyl group.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorinated aromatic core enhances efficacy and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorinated aromatic units into polymer chains, altering properties like chemical resistance, thermal stability, and surface energy.
• Chemical Research & Development: A versatile building block in academic and industrial R&D for exploring new reactions and creating complex molecular architectures.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments with unique colorfastness and optical properties.

Basic Information

Product Name	Methyl 3-Hydroxy-4-(Trifluoromethyl)Benzoate
CAS No.	126541-88-6
Molecular Formula	C9H7F3O3
Molecular Weight	220.15 g/mol
Synonyms	3-Hydroxy-4-(trifluoromethyl)benzoic acid methyl ester; Methyl 3-hydroxy-α,α,α-trifluoro-p-toluate; Benzoic acid, 3-hydroxy-4-(trifluoromethyl)-, methyl ester; 4-(Trifluoromethyl)salicylic acid methyl ester; Methyl 4-(trifluoromethyl)salicylate
EINECS	Contact for details

Quality Control

Our production of Methyl 3-Hydroxy-4-(Trifluoromethyl)Benzoate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure consistency and reliability. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support custom purity requirements for specific R&D or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.