Description

3-Hydroxy-4-Trifluoromethylbenzoic Acid is a high-value fluorinated aromatic building block characterized by its benzoic acid core substituted with both a hydroxyl and a trifluoromethyl group. This unique structure makes it a critical intermediate for synthesizing advanced pharmaceutical compounds and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is essential for R&D and production chemists in the life sciences and specialty chemical sectors seeking to develop novel active ingredients with improved properties.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group contributes to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its ability to modify electronic properties.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing their chemical resistance, thermal stability, and surface properties.
• Complex Ligand & Catalyst Development: Useful in organometallic chemistry for creating specialized ligands that can modulate catalyst performance in asymmetric synthesis.
• Advanced Material Research: Investigated as a building block for metal-organic frameworks (MOFs) and other porous materials with potential applications in gas storage and separation.

Basic Information

Product Name	3-Hydroxy-4-Trifluoromethylbenzoic Acid
CAS No.	126541-87-5
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	4-(Trifluoromethyl)-3-hydroxybenzoic acid; 3-Hydroxy-4-(trifluoromethyl)benzoic acid; Benzoic acid, 3-hydroxy-4-(trifluoromethyl)-; 3-Hydroxy-α,α,α-trifluoro-p-toluic acid
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-4-Trifluoromethylbenzoic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets exacting standards for research and industrial use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.