Description

Fmoc-[15N]Val-Oh is a stable isotope-labeled derivative of the amino acid valine, protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is essential for advanced peptide synthesis, particularly in Solid-Phase Peptide Synthesis (SPPS), where it enables the precise incorporation of a nitrogen-15 labeled valine residue. It is primarily used by researchers and manufacturers in pharmaceutical development, proteomics, and metabolic research to create isotopically labeled peptides for mass spectrometry, NMR spectroscopy, and tracer studies.

Application

• Synthesis of Isotopically Labeled Peptides: Critical building block for incorporating 15N-labeled valine into peptides for structural and functional studies.
• Biomolecular NMR Spectroscopy: Used to produce peptides with site-specific 15N labels, facilitating the determination of protein structure, dynamics, and interactions.
• Quantitative Proteomics & Mass Spectrometry: Enables the creation of internal standards for accurate quantification of proteins and peptides in complex biological samples.
• Metabolic Pathway Tracing: Serves as a tracer in studies investigating amino acid metabolism and protein turnover.
• Pharmaceutical R&D: Employed in the development and characterization of peptide-based drug candidates and biomarkers.
• Academic Research: A key reagent in chemical biology and biochemistry laboratories for advanced peptide engineering.

Basic Information

Product Name	Fmoc-[15N]Val-Oh
CAS No.	125700-35-8
Molecular Formula	C20H2115N O4
Molecular Weight	354.39 g/mol (for 15N isotopologue)
Synonyms	Fmoc-L-valine-15N; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine-15N; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-methylbutanoic acid-15N; Fmoc-Val-15N-OH; Fmoc-15N-Val-OH; 9-Fluorenylmethyloxycarbonyl-15N-valine; Nα-Fmoc-L-valine-15N
EINECS	Contact for details

Quality Control

Our Fmoc-[15N]Val-Oh is manufactured under strict quality control protocols to ensure high isotopic and chemical purity, critical for sensitive research applications. Each batch is analyzed via HPLC, NMR, and Mass Spectrometry to confirm identity, isotopic enrichment, and purity. A comprehensive Certificate of Analysis (COA) detailing these specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (15N)	≥ 98 atom %
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.